Highlights
Now available at dbGAP: Division of Cancer Epidemiology and Genetics (DCEG) Imputation Reference Dataset, a new resource for imputation of SNPs for existing and future genome-wide association studies (GWAS). For more details, Wang Z, et al. Improved Imputation of common and Uncommon SNPs with a New Reference Set. in Nat Genet. 2011 Dec 27;44(1):6-7 and Nature Precedings Nov 7, 2011.
CGF investigators, Drs. Meredith Yeager, Kevin Jacobs, Zhaoming Wang, and Stephen Chanock, speak on genomic approaches used in identifying and characterizing cancer susceptibility regions in the human genome, and future trends in this research at GWAS 2011: Opportunities and Challenges in Anhui, China. This conference was organized by Nature Genetics in association with Anhui Medical University in China.
Also read the accompanying commentary in Nature Genetics 2011 Jun 28;43(7):613.
With remarkable advances in genomic technologies, the National Cancer Institute established the Core Genotyping Facility (CGF) to investigate the contribution of germline genetic variation to cancer susceptibility and outcomes. Working in concert with epidemiologists, biostatisticians and basic research scientists in the intramural research program, the CGF has developed the capacity to conduct genome-wide association studies and candidate gene approaches to identify the heritable determinants of various forms of cancer.
AffiliationsThe Core Genotyping Facility (CGF) is within the Division of Cancer Epidemiology and Genetics (DCEG) of the National Cancer Institute (NCI) and supported by SAIC-Frederick.
Abnet CC, et al.Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies Hum Mol Genet. 2012 May 1;21(9):2132-41. Epub 2012 Feb 8
Han SS, et al. The chromosome 2p21 region harbors a complex genetic architecture for association with risk for renal cell carcinoma Hum Mol Genet. 2012 Mar 1;21(5):1190-200. Epub 2011 Nov 23.
Wu X, et al. A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23. Hum Mol Genet. 2011 Nov 1.
